《Table 1The role of dysregulated XPO5 in different cancers》

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《The Role of Exportin-5 in MicroRNA Biogenesis and Cancer》

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Note:PTM，post-translational modification；SNP，single nucleotide polymorphism；HCC，hepatocellular carcinoma；CRC，colorectal cancer；NSCLC，non-small cell lung cancer.

Nuclear export of pre-mi RNAs is accurately regulated in normal cells and its dysregulation could cause abnormal expression of mature mi RNAs in cancer cells.Strikingly，more pre-mi RNAs are found to be retained in the nucleus of both cancer cells and tumors，when compared with normal cells and normal tissues[17].Using real-time PCR，Lee et al have profiled the expression of 225 pre-mi RNAs and mature mi R-NAs in 22 different human tissues，37 human cancer cell lines，as well as 16 pancreas and liver tissues/tumors.They find that a large number of MIR genes are transcribed and processed into pre-mi RNAs，but not processed to mature mi RNAs in cancer cells，indicating defects in the pre-mi RNA nuclear export by XPO5 in human tumors[17].The abnormal function of XPO5 could be caused by genetic or epigenetic change of XPO5 as well as abnormal expression level or posttranslational modifications（PTMs）of XPO5 protein（Table 1）.