《Table 2 Extended criteria currently in use》

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《Hepatocellular carcinoma-time to take the ticket》

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Tumor biology helps with better predicting the risk of recurrence.The gold standard remains biopsy of the tumor with histopathological examination.However，this invasive procedure is often fraught with dangers，such as bleeding and needle track seeding.In addition，ascites in patients with decompensated cirrhosis is another contraindication for biopsy.To overcome this problem，other biomarkers are being used to predict tumor behavior.These biomarkers include alpha-fetoprotein（AFP），des-gamma carboxy prothrombin，and positron emission tomography（PET）scan.A list of criteria that use biomarkers（Table 3）and the associated survival rates（Figure 2）are presented below.