《Table 4 Composite treatments used in the current literature》

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《Treatment of laryngopharyngeal reflux disease: A systematic review》

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The addition of prokinetics to PPIs is still controversial in GERD[96]，despite their role in the increase of the esophageal sphincter pressure[94，97，98].Six studies showed interest in the role of prokinetics for the management of LPRD[17，38，48，51，57，79]and these authors reported mixed evidence about the superiority of PPIs and prokinetics over PPIs alone[99].Precisely，two RCTs suggested that the addition of prokinetics to PPI（s）would be associated with better symptom improvement[38，51]，while the study by Hunchaisri et al[48]did not find similar findings.The controversy about the efficacy ofprokinetics in LPRD illustrates the lack of evidence in the occurrence of esophageal dysmotility disorder in this condition[100，101].