《Table 1 Sirtuins localization and function》

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《Sirtuins in B lymphocytes metabolism and function》

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ADP:Adenine diphosphate；SIRT:Sirtuin.

In yeasts，four SIRs have been identified（SIR1-4），whereas in humans and mice seven homologs（SIRT1-7）have been described[27].SIRTs can be divided according to a specific terminology based on their structural sequence:SIRT1，2 and 3（class I），SIRT4（class II），SIRT5（class III）and SIRT6 and 7（class IV）[28].Despite the high structural similarity among the SIRTs，each one presents unique features regarding their enzymatic activities，cellular sublocations，and molecular targets as shown in Table 1.Therefore，the classification based on cellular sublocation has been most widely used，being SIRT1，3，6 and 7 classified as nuclear（SIRT1 may also be found in cytoplasm），SIRT2 as cytoplasmic（but it can also be found in nucleus）and SIRT3，4 and 5 as mitochondrial proteins[29].