《Table 3 Liver function including liver enzymes, routine blood tests, and coagulation function tests

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《Clinical characteristics of non-alcoholic fatty liver disease in Chinese adult hypopituitary patients》

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aP<0.05 vs the cirrhosis group.bP<0.01 vs the cirrhosis group.cP<0.001 vs the cirrhosis group.NAFLD:Non-alcoholic fatty liver disease；ALT:Alanine aminotransferase；ALB:Albumin；TBil:Total bilirubin；DBil:Direct bilirubin；GGT:γ-glutamyltransferase；ALP:Alkalin

A total of 36 male and 14 female patients with hypopituitarism and/or panhypopituitarism were included in the present study.Their mean age was 26.9years（range from 18.0 to 41.5 years）.The frequency of fatty liver on abdominal ultrasonography was 54.0%.A total of two patients were diagnosed as cirrhotic by liver biopsy，while five patients were diagnosed as cirrhotic by the development of clinically evident complications of liver disease as indicated in the Materials and Methods section.Three cirrhotic patients were decompensated，one of whom had upper gastrointestinal bleeding，another two had hypersplenism，ascites，esophageal and gastric varices，and hepatopulmonary syndrome.The clinical characteristics of hypopituitary patients with NAFLD and without NAFLD are shown in Table 1，and a comparative analysis was completed.No significant differences were noted in the gender ratio among patients with cirrhosis，those with NAFLD，and those without NAFLD.Cirrhotic patients were younger than NAFLD patients（P=0.009），with no significant difference in the course of hypopituitarism.The course of hypopituitarism of cirrhotic patients was significantly longer than that of patients without NAFLD（median course 13.0 years and 3.0 years，respectively，P=0.023），although there was no significant difference in the age between the two groups.