《Table 4 Studies included for study of plasmapheresis in acute-on-chronic liver failure》

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《Plasma exchange in patients with acute and acute-on-chronic liver failure: A systematic review》

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As aforementioned，only few[3，6，18，33]studies used a strict consecutive daily or every other day 3-d therapy plasma exchange regime as in the open-RCT by Larsen et al[3].Instead，most studies continued plasma exchange till patient dies，or improves clinically，or receives a liver transplant at a range of intervals from every other day to intermittent（as and when necessary）.Buckner et al[7]reported an interesting finding in their case series where a patient with halothane toxicity and acute liver failure received plasma exchange with 5-10 L of plasma almost daily for 37 d before she roused from coma.Few studies did not include detailed information on the frequency of plasma exchange[5，29，34.