《Table 1 Puerarin solution and microemulsion transport across Calu-3 cells monolayers (mean±SD)》

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《鼻脑递送:葛根素在嗅神经鞘细胞的摄取及在Calu-3细胞的转运研究（英文）》

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Note:Papp.permeability；A.apical side；B.basolateral side.Compared Puerarin solution（40μg/m L），*P<0.05.

The PAPP（A→B）value of puerarin solution was（1.19±0.11）and the PAPP（B→A）value was（1.21±0.06）.The B→A/A→B permeability RE of puerarin was（1.02±0.08）in the cell models，which suggested that puerarin was not P-gp substrate.This was consistent with the results of our previous study，which showed that the transport of puerarin on MDCK and MDCK-MDR1 cell monolayers was not concentration-dependent and saturable and behaved purely passive diffusion.Results showed significant increasing PAPP value of puerarin in both directions（P<0.05）when transported with puerarin microemulsion.The Papp（A→B）value was（1.64±0.08）and the Papp（B→A）value was（1.86±0.17）and RE of puerarin was（1.14±0.07）（Table 1） .