《Table 1–pH and density (mean±SD) forβ-CyD solutions and its respective solvents (n=3) .》

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《Physicochemical properties of β-cyclodextrin solutions and precipitates prepared from injectable vehicles》

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PYR and itsβ-CD solutions showed the highest density and that of DMSO and its systems were slightly lower.NMP and its related solutions gave the lowest density among three solvents.The more the concentration of intactβ-CD，the more increased density of the solution were attained（Table 1）.The high density of PYR related with its high viscosity and could affect the diffusion property of these solvent.In addition the higher density of the developed solutions than water indicated that they could transform into matrix-like after exposure an aqueous environment and could deposit at bottom of target site such as periodontal pocket properly.