《Table 1 Number of intact pyramidal cells and dendritic spines from secondary and tertiary apical de

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《Protective mechanism of testosterone on cognitive impairment in a rat model of Alzheimer's disease》

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Data are expressed as the mean±SD（n=10；one-way analysis of variance followed by the least significant difference post hoc test）.*P<0.05，vs.AD group.AD:AD group；T:testosterone group；F:flutamide group；F+T:flutamide+testosterone group.AD:Alzheimer’s dise

There was a significant difference between the AD and testosterone groups in the number of intact pyramidal cells in the hippocampal CA1 region（P<0.05）.A significant elevation in the number of intact hippocampal pyramidal cells was observed in the testosterone group using Nissl staining（Table 1 and Figure 3）.Administration of flutamide combined with testosterone（Figure 3D）resulted in a marked decrease in the number of intact hippocampal pyramidal cells compared with testosterone alone（Figure 3B），while no significant differences were found between the AD（Figure 3A）and flutamide groups（Figure 3C）.