《Table 1 Contactins:summary of their main characteristics》

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《Contactins in the central nervous system: role in health and disease》

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*The expression pattern of all proteins in the table is mentioned in the context of humans unless stated otherwise.CSF:Cerebrospinal fluid；CNTNAP:contactin associated proteins；PTPRZ:protein tyrosine phosphatase，receptor-type，Z polypeptide 1；PTPα:recepto

The importance of contactins have been elucidated not only in health as described above but also in disease.Recent studies have revealed the role of improper functioning，incorrect cellular localization or genetic aberrations related to contactins in neurological and neurodevelopmental disorders such as autism（Burbach and van der Zwaag，2009；Kumar and Christian，2009；van Daalen et al.，2011）and neuro-developmental delay（Fernandez et al.，2004；Roohi et al.，2009）.Here，we focus on the recent progresses in the field of contactins and their roles in CNS development and maintenance of CNS physiology（summary in Table 1 and Figure 2）.In this review，we will summarize the expression pattern，physiological functions，and the roles in synapse and myelin formation during neurodevelopment for each of the six contactins as well the implications of dysfunction of contactins in neurological disorders.