《Table 2 Synthesis of the aldo-quinazolinones 3a～3g through the condensation of the unprotected sacc

  提示：宽带有限、当前游客访问压缩模式

本系列图表出处文件名：随高清版一同展现

《碘诱导的醛糖与o-氨基苯甲酰胺的氧化缩合合成糖基喹唑啉酮（英文）》

1. 获取 高清版本忘记账户？点击这里登录

1. 下载图表忘记账户？点击这里登录

We initiated our experiment by examining the reaction of D-ribose（1a）with o-aminobenzamide（2a）in dimethyl sulfoxide（DMSO）solution at 60℃（Table 1，Entry 1）according to the method for the aromatic aldehydes.[13]However，the reaction didn’t occur.Subsequently，the reaction was carried out in methanol solution at 40℃in the presence of some Lewis acids Fe Cl3[19]or CuCl2[20]（Table1，Entries 2，3），but the reactions still didn’t proceed.When using Ac OH as the catalyst，[33]the reaction could yield small amount of the intermediate A（Scheme 1，two pairs of inseparable amino glycosides includingα/β-furanosides andα/β-pyranosides）（Table 1，Entry 4）.Finally，iodine（I2）was added to promote the reaction（Table 1，Entry 5）.[21]The reaction could succeed in generating the target ribo-quinazolinone 3a with a low yield of 12%，although the iodine-induced reaction was very complicated.