《Table 1 Molecular weight and chemical composition of different comb-like PHPMA-DOX conjugates》

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《Comb-like Poly(N-(2-hydroxypropyl) methacrylamide) Doxorubicin Conjugates: The Influence of Polymer Architecture and Composition on the Biological Properties》

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a C，H and B stand for the comb-like backbone，HPMA and BHMAGG，respectively.The numbers following C/H/B represented the repeating units of HEMA-Br on the backbone and the repeating units of HPMA and BHMAGG on each side chain；b Comb number of the polymers

To investigate the influences of comb number and comb length on their physicochemical and biological properties，macro-initiators C15 and C50 were used to initiate the copolymerization of HPMA with BHMAGG（Fig.2a），another functional monomer commonly used for conjugating anti-cancer drug DOX via an acid-sensitive hydrazone bond[36，49].The reaction was accomplished under 30°C and[M]0:solvent of 1:30 with conversion of 40%-50%for all copolymers.After employing fractional precipitation methods，copolymers C15-g-P（HPMA70-co-BHMAGG3）（C15-H70（B3）） ，C15-g-P（HPMA130-co-BHMAGG5）（C15-H130（B5）） ，and C50-g-P（HPMA70-co-BHMAGG3）（C50-H70（B3）） were obtained after removing the high molecular weight portions which may contain cross-linked polymers.The molecular weight and chemical composition are summarized in Table 1.The PDI values of C15-H70（B3），C15-H130（B5）and C50-H70（B3）were 1.29，1.27 and 1.24，respectively，indicating the well-defined architectures（Fig.2b and Fig.S5 in ESI）.