《Table 4–The effect of selected CS molecular weight and concentration on surface porosity%for plain

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CS coated PLGA formulae were visualized using SEM.SEM micrographs（Fig.1 B–D）show the deposition of CS onto the surface of PLGA MPs at different CS concentrations compared to uncoated ones.SEM images reveal the disappearance of surface pores with the deposition of CS coating.By visual inspection and surface porosity data（Fig.1 E），it can be noted that the number of surface pores was inversely related to the CS concentration.Hence，CS concentration of5 mg/ml showed the most efficient blocking（surface porosity decreased from 15%±6%to 1.3%±0.02%，P<0.001）compared to the higher concentrations 10 and 15 mg/ml（surface porosity was 2.9%±1.3%and 6.6%±4%respectively，P<0.001，Table 4）.These findings confirm the reason for the highest LC%achieved with 5 mg/ml where the polymer diffusion into the pores towards the surface reached its maximum.