《Table Pathological score of knee cartilage and synovial membrane in papain-induced osteoarthritis m
本系列图表出处文件名:随高清版一同展现
《Intra-articular delivery of tetramethylpyrazine microspheres with enhanced articular cavity retention for treating osteoarthritis》
The pharmacokinetic parameters of TMP in joint tissue and synovial fluid were listed in Table 1.The area under the curve(AUC)of freeze-dried microspheres in the joint tissue was extremely large,13.2 times that of the TMP solution and 7.9 times that of the vacuum-dried microspheres.The AUC of the freezedried microspheres in synovial fluid were 17.6 and 11.6 times larger than that of TMP solution and vacuum-dried microspheres,respectively.The mean residence time(MRT)of freeze-dried microspheres in joint tissue was 9.2 times longer than that of TMP solution and 4.6 times longer than that of vacuum-dried microspheres.Thus,freeze-dried microspheres not only exhibited localized high concentrations in joint tissue,but also displayed a long retention time for one month.
图表编号 | XD00186263100 严禁用于非法目的 |
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绘制时间 | 2018.05.01 |
作者 | Xiuping Zhang、Yang Shi、Zhiyue Zhang、Zhenlei Yang、Guihua Huang |
绘制单位 | Department of Pharmaceutical Science, Shandong University、Department of Pharmaceutical Science, Shandong University、Department of Pharmaceutical Science, Shandong University、Department of Pharmaceutical Science, Shandong University、Department of Pharmaceu |
更多格式 | 高清、无水印(增值服务) |
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