《Table 1–Process variables in the high shear mixer granulator investigated in the study.250 rpm and

  提示：宽带有限、当前游客访问压缩模式

本系列图表出处文件名：随高清版一同展现

《DEM modeling of high shear wet granulation of a simple system》

1. 获取 高清版本忘记账户？点击这里登录

1. 下载图表忘记账户？点击这里登录

The wet granulation experiments were performed in a 1 l bowl attachment of the KG5 granulator（Key International，NJ）.The bowls were loaded with fast flow lactose（d50=67μm）at a specified fill level and the impeller and chopper were turned on for a dry run of 2 min.The telescopic spray pump was then turned on to give a specified volumetric flow rate of the binder till a specified end point based on the liquid volume percentage，which corresponded to a plateau region on the impeller power consumption curve.The liquid addition rate from the pump was calibrated prior to every run.2–3 g of the wet granules were sampled for particle size measurements every 2 min and then dried at 40°C in a laboratory tray oven.The wet granules were dried till the moisture content of 2.5%or lower was achieved as measured using a SARTORIUS MA 100 moisture analyzer.The operating conditions were optimized with respect to the lactose–water system parametrically analyzed with respect to processing variables of interest.Table 1 lists the process parameters under investigation in the current study.Progress of the HSWG run was monitored from the measurements of temporal evolution of the dynamic strength and particle size of the powder bed.These measurements have been described in detail below.