《Table 5 Comparison of progression-free survival among groups created based on regression change and

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《Unnecessity of lymph node regression evaluation for predicting gastric adenocarcinoma outcome after neoadjuvant chemotherapy》

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1Groups A+B vs Groups C+D.A:True negative lymph nodes（LNs）with no evidence of a preoperative therapy effect；B:No residual metastasis but presence of regression change in LNs；C:Residual metastasis with regression change in LNs；D:Metastasis with minimal or

All of the examined LN specimens were embedded in paraffin，and four micrometer tissue sections were stained with hematoxylin and eosin.The median number of resected LNs was 24（3-58）per case.The histopathological evidence of regression change in LNs was defined as the presence of fibrosis，aggregation of foamy histocytes or accumulation of mucin pools in LN parenchyma[6]，which is shown in Figure 1.We classified tumor regression and residual tumor in LNs into four groups:A，true negative LNs with no evidence of a preoperative therapy effect；B，no residual metastasis but presence of regression change in LNs；C，residual metastasis with regression change in LNs；and D，metastasis with minimal or no regression change in LNs（Table 1 and Figure 2）.All of the sections were reviewed by three experienced pathologists（Zhu YL，Yue JY and Xue LY）.For a controversial diagnosis，three pathologists reviewed the sections on a multi-headed microscope until reaching an agreement.