《Table 1.Comparison of Salivary Flow of Mice among Groups (±s)》

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《Protective Effect of Zengye Decoction(增液汤)on Submandibular Glands in Nonobese Diabetic Mice》

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Notes:P<0.05，compared with the normal group；△P<0.05，compared with the model group

The whole saliva was collected.Whole saliva primarily represents a combination of parotid and SMG secretions，and a very minor component from the sublingual，minor salivary，nasal，and tracheal glands.There were no differences between the four groups at the age of 15 weeks.The mean salivary flow of the normal group remained at the baseline during the study.However，the other groups showed a progressive decline in salivary flow starting at17 weeks of age.The salivary flow was thereafter significantly lower in the model group than in the normal group（P<0.05）.The mice treated with HCQ and ZYD exhibited less reduction in salivary flow，compared with the model group（P<0.05）.Significant differences between the HCQ and ZYD groups occurred at 17 weeks and 20 weeks of age（Table 1）.