《Table 2 Protein levels (pg/mL) of TGF-β1, GDNF, bFGF and ANG1 (astrocyte secretory proteins) in the

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《Structural and functional damage to the hippocampal neurovascular unit in diabetes-related depression》

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*P<0.05，**P<0.01，vs.NVU group；#P<0.05，vs.NVU model group（NVU+G&P，NVU+glucose+corticosterone）.NE:Neuron；AS:astrocyte；BM:brain microvascular endothelial cell；NVU:neurovascular unit；G&P:glucose and corticosterone；TGF-β1:tumor growth factor beta 1；GDNF:

As shown in Table 1，expression of the secretory protein LIF in brain microvascular endothelial cells was decreased in the astrocytes+brain microvascular endothelial cells group and NVU group after DD，compared with the corresponding controls（P<0.01）.Moreover，LIF expression was lowest in the astrocytes+brain microvascular endothelial cells group exposed to hyperglycemia and corticosterone（P<0.01）.Therefore，the secretory function of brain microvascular endothelial cells is reduced by simulated DD.Secretory function was better in the NVU co-culture system compared with the astrocytes+brain microvascular endothelial cells system.