《Table 1 Levels of LIF, a BM secretory protein, in the hippocampal NVU triple cell co-culture system

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《Structural and functional damage to the hippocampal neurovascular unit in diabetes-related depression》

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Data are expressed as the mean±SD（one-way analysis of variance followed by Dunnett’s post hoc test）.**P<0.01，vs.NVU group；##P<0.01，vs.NVU model group（NVU+G&P，NVU+glucose+corticosterone，AS+BM+G&P）；$$P<0.01，vs.AS+BM group.AS:Astrocyte；BM:brain mic

As shown in Table 1，expression of the secretory protein LIF in brain microvascular endothelial cells was decreased in the astrocytes+brain microvascular endothelial cells group and NVU group after DD，compared with the corresponding controls（P<0.01）.Moreover，LIF expression was lowest in the astrocytes+brain microvascular endothelial cells group exposed to hyperglycemia and corticosterone（P<0.01）.Therefore，the secretory function of brain microvascular endothelial cells is reduced by simulated DD.Secretory function was better in the NVU co-culture system compared with the astrocytes+brain microvascular endothelial cells system.