《Table 2 Results of pathological analysis》

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《Protective effects of Rutin against methanol induced acute toxic optic neuropathy:an experimental study》

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C:Controls；MTX:Methotrexate group；MTM:Methotrexate+methanol group；MTME:Methotrexate+methanol+ethanol group；MTMR:Methotrexate+methanol+rutin group；8-OHd G:8-hydroxy-2 deoxyguanine.aStatistically significantly different when compared with control group；bSta

At the end of the study，all rats were evaluated without any failure.Regarding the biochemical results，there were statistically significant differences in 8-OHd G，IL-1β，TNF-α，MDA，MPO，t GSH and SOD levels between groups（Table 1）.The highest tissue 8-OHd G and serum IL-1β，TNF-α，MDA，and MPO levels were determined in MTM and MTME groups while the anti-oxidant t GSH and SOD levels were the lowest in those groups.In MTMR group，tissue 8-OHd G，and serum IL-1β，MDA，and MPO levels were similar with the healthy controls but significantly different than other groups.In that aspect Rutin was effective to prevent the increases in systemic oxidative stress and inflammation markers.