《Table 1Selected differentially expressed proteins (DEPs) regulated following 15μM treatment of MS17

《Table 1Selected differentially expressed proteins (DEPs) regulated following 15μM treatment of MS17   提示：宽带有限、当前游客访问压缩模式
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《"Identification of commonly regulated protein targets and molecular pathways in PC-3 and DU145 androgen-independent human prostate cancer cells treated with the curcumin analogue 1,5-bis(2-hydroxyphenyl)-1,4-pentadiene-3-one"》


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PC-3 and DU145 cells were treated with 3×EC50（15μM）dose of MS17 and DMSO（control）respectively for 24 h.Using the PDQuest software，protein spots with significant P-value of P<0.05 and a fold change over 1.5-fold in MS17 treated cells compared to control cells in replicate gels were averaged and quantified.Overall，a total of 20 significant protein spots were detected in PC-3 cells while 24spots were detected in DU145 cells，as indicated by the specific spot number（SSP number）.Representative 2-DE gel images of control and MS17-treated cells in PC-3 and DU145 cells are respectively shown in Figures 1 and 2.Protein identification by PEAKS software and UniProt/SwissProt database identified a total of 46 DEPs in PC-3 cells and 47 DEPs in DU145 cells.Amongst these DEPs，a total of 10 up-and 36 down-regulated（Table 1）were obtained in PC-3 cells while 24 up-and 23 down-regulated（Table 2）DEPs were selected in DU145 cells.The significant regulated proteins were then ontologically classified based on their biological processes or molecular functions.

图表编号XD00187344400    严禁用于非法目的
绘制时间2018.09.01
作者Kamini Citalingam、Faridah Abas、Nordin H.Lajis、Iekhsan Othman、Rakesh Naidu
绘制单位Jeffery Cheah School of Medicine and Health Sciences, Monash University Malaysia, Jalan Lagoon Selatan、Laboratory of Natural Products, Faculty of Science, Universiti Putra Malaysia、Department of Food Science, Faculty of Food Science and Technology, Univer
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