《Table 1 The GO analysis results of serum proteins differentially expressed between 4w and 12w dnTGF

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《Proteomic analysis reveals distinctive protein profiles involved in CD8~+ T cell-mediated murine autoimmune cholangitis》

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Count:the number of proteins with altered expression within the individual GO category.

The serum protein expression profiles in 4-and 12-week-old dnTGFβRII mice and B6 mice（n=8 each time point）were analyzed using the SOMAscan platform（Supplementary Table S1）.Protein abundance is shown in Figure 1a.A total of 115proteins were differentially expressed，including 54 proteins that were significantly increased and 61 proteins that were significantly decreased in the serum of 12-week-old dnTGFβRII mice compared to that of 4-week-old dn TGFβRII mice（Figure 1b）.The top 38 differentially expressed proteins（qo0.01）were assigned to 7 functional annotation categories（Table 1）.Additionally，87 proteins were significantly increased，and 45 proteins were significantly decreased in the serum of12-week-old dn TGFβRII mice compared with that of 12-weekold B6 mice.Of those，the top 45 differentially expressed proteins（qo0.01）were assigned to 61 functional annotation categories（Supplementary Table S2）.Only 3 overexpressed proteins were found in the serum of 4-week-old dnTGFβRII mice compared with that of 4-week-old B6 mice，consistent with minimal disease in dnTGFβRII mice at this early age.23IL18bp（Interleukin 18 Binding Protein）was increased in both4-and 12-week-old dn TGFβRII mice.Among the differentially expressed proteins in the serum of 12-week-old dnTGFβRII mice vs.4-week-old dn TGFβRII mice，seventy-eight proteins，including IgG，IFN-γand IL-2 sRγ（IL-2 soluble receptor gamma），were increased in dn TGFβRII mice but not B6 mice（12-week-old vs 4-week-old B6 mice）（Supplementary Table S3） .Consistent with a previous proteomic study，24the number of protein alterations in the serum of 4-week-old and 12-weekold B6 mice was greater than that in either 4-or 12-week-old dnTGFβRII mice，indicating the magnitude of protein changes during development in the presence and absence of autoimmunity.