《乳腺癌细胞病理学》

FOREWORD1

PREFACE1

1．INTRODUCTION1

Contents1

1．Incidence and Mortality2

2．Diagnostic Accuracy3

3 Problem of Inadequate Smears4

4．False Negative Rate6

5．False-Positive Rate7

B．Sensitivity Rate in Histological Typing of Breast Carcinoma9

6．Classification of Tumour Types and Their Positive Rate9

A．Histological Classification of Breast Tumours by WHO9

7 Comparison of Carcinoma Detection Rates with Various Methods10

8．Technical Notes:Technique,Indication,Complications11

2．ANATOMY AND HISTOLOGY OF THE MAMMARY GLAND13

1．Duct System14

2．Stroma14

3．Areola and Nipple14

7．Mammary Gland in the Male15

6．Menstrual Cyclic Changes15

5．Different Periods of Life15

4．Ductal Epithelium15

3．THE CYTOLOGY OF NIPPLE SECRETION26

1．Introduction27

2．Endocrine Disorders31

3．Inflammation32

4．Duct Ectasia(Periductal Mastitis)32

5．Calcification32

7．Intraductal Papilloma33

8 The Cytologic Features of Benign Smears33

6．Benign Ductal Epithelial Hyperplasia33

9 The Cytologic Features of Malignant Smears34

10．The Characteristics of Malignant Cell Clusters36

11．The Characteristics of Malignant Single Cells37

12．Comparison Between Benign and Malignant Smears37

4．EPITHELIAL AND STROMAL CELLS OF NORMAL BREAST AND NEIGHBOURING93

ORGANS93

7．Histiocytic Cells94

6．Stromal Tissue94

5．Fat Tissue94

4．Epidermal Cells and Epidermal Fragments94

3．Myoepithelial Cells94

2．Cells From Terminal Ducts/Acini94

1．Benign Ductal Cells94

8．Bone Marrow Cells95

5．BREAST IN PREGNANCY AND LACTATION PERIOD109

1．Pregnancy110

2．Lactation110

4．Lactating Adenoma111

3．Proliferative Ductal Cells of Pregnancy and Lactation111

6．INFLAMMATORY AND TUMOUR-LIKE LESIONS125

1．Inflammatory Lesions126

A．Subacute and Chronic Mastitis126

B．Granulomatous Mastitis126

C．Plasma Cell Mastitis126

D．Tuberculosis126

2．Fat Necrosis127

7．BREAST CYSTS140

1．Cystic Disease141

3．Diagnostic Accuracy of Cytologic Examination in FNAB142

2．Gross Cysts142

4．Subclassification of Gross Cysts143

A．Milk Cyst(Galactocele)143

B．Inflammatory Cyst143

C．Simple Cyst143

D．Pseudoepithelial Cyst143

E．Apocrine of“Tension”Cyst144

F．Intracystic Papilloma144

G．Intracystic Carcinoma144

5．Comparative Cystic Fluid and Cytologic Pattern of Gross Cyst145

8．EPITHELIAL HYPERPLASIA AND ATYPICAL HYPERPLASIA171

1．Histological Finding172

A．Ductal Hyperplasia．172

B．Lobular Hyperplasia172

C．Atypical Ductal Hyperplasia172

D．Atypical Lobular Hyperplasia172

2．Cytological Finding173

A．Ductal and Lobular Hyperplasia173

B．Atypical Ductal and Lobular Hyperplasia173

C．Hyperplastic Cells of Myoepithelial Origin173

4．Relationship of Benign Epithelial Hyperplasia to Cancer174

3 Comparision of Differentiated Diagnosis174

9．BENIGN EPITHELIAL TUMOURS209

1．Intraductal Papilloma210

2．Adenoma of Nipple(Subareolar Adenoma)211

10．MALIGNANT CRITERIA OF PRIMARY BREAST CARCINOMA230

1．Introduction231

2．Cytologic Criteria of Carcinoma231

A Malignant Features of Single Cells232

3．Common Cytomorphologic Presentation in Cellular Size of Breast Carcinoma234

C Indirect Criteria of Malignancy234

B Malignant Findings in Cell Clusters234

11．CORRELATION BETWEEN HISTOLOGY AND CYTOLOGY IN BREAST265

CARCINOMA(Ⅰ)265

1．Introduction266

2．Intraductal Carcinoma or Ductal Carcinoma in Situ(DCIS)267

3．Lobular Carcinoma in Situ(LCIS)267

4．The Sensitivity Rate of Cytological Diagnosis for Noninvasive Carcinoma268

5．Invasive Ductal Carcinoma268

6．Invasive Lobular Carcinoma269

CARCINOMA(Ⅱ)332

12．CORRELATION BETWEEN HISTOLOGY AND CYTOLOGY IN BREAST332

7．Tubular Carcinoma333

8．Adenoid Cystic Carcinoma333

9．Carcinoma with Carcinoid Features334

10．Medullary Carcinoma334

11．Papillary Carcinoma335

13．CORRELATION BETWEEN HISTOLOGY AND CYTOLOGY IN BREAST367

CARCINOMA(Ⅲ)367

13．Signet-Ring Cell Carcinoma368

12．Mucinous Carcinoma368

14．Secretary Carcinoma369

15．Lipid-Rich Carcinoma369

16．Apocrine Carcinoma370

17．Small Cell Carcinoma370

18．Carcinoma with Squamous Cell Type370

19．Carcinoma with Spindle Cell Type372

20．Carcinoma with Cell of Cartilagenous and Osseous Type372

21．Paget s Disease of the Nipple373

14．MIXED CONNECTIVE TISSUE AND EPITHELIAL TUMOURS424

B．Histological Pattern425

A．Introduction425

1．Fibroadenoma425

C．Cytological Pattern426

D．Uncommon Cytologic Pattern426

2 Phyllodes Tumours(Cystosarcoma Phyllodes)426

A．Benign Phyllodes Tumour427

B．Malignant Phyllodes Tumour427

3．Carcinosarcoma427

15．MISCELLANEOUS TUMOURS458

3．Granular Cell Tumour(Myoblastoma)459

5．Malignant Fibrous Histiocytoma459

4 Dermatofibrosarcoma Protuberans459

1．Tumour-Like Lesions---Duct Ectasia459

2．Lipoma459

A．Tumour-Like Lesions and Soft Tissue Tumours459

6．Stromal Sarcoma460

7．Liposarcoma460

8．Malignant Myoepithelioma460

9．Angiosarcoma460

B．Tumours of Haematopoietic and Lymphoid Tissue460

3．Primary Malignant Lymphoma461

1．Leukemic Involvement461

2．Benign Lymphatic Hyperplasia461

16．PATHOLOGIC CONDITIONS IN MALE BREAST491

1．Benign Proliferative Conditions(Gynecomastia)492

2．Carcinoma492

17．METASTATIC MALIGNANT TUMOURS INVOLVING BREAST504

1．Frequency505

2．Tumour Types505

3．Cytology505

18．THE CYTOLOGY OF DIFFICULT DIFFERENTIAL DIAGNOSIS520

1．Differentiation Between Benign and Malignant Cellular Criteria521

2．Differential Characteristics of Normal,Hyperplastic,Atypical Hyperplastic and Malignant CellClusters522

3．Differentiation Between Mastopathy and Fibroadenoma522

4．Differentiation Between Fibroadenoma and Phyllodes Tumour523

5．Differential Characteristics of Ductal Carcinoma and Lobular Carcinoma523

6．Differential Characteristics of Intraductal Papilloma and Papillary Carcinoma524

7．Differential Characteristics of Lymphatic Hyperplasia,Non-Hodgkin s Lymphoma andHodgkin s Disease525

REFERENCES544

INDEX553