《Table 1Grouping scheme used in acute toxicity assay.》

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《Synergistic effect and different toxicities of adjuvant components of Realgar–Indigo Naturalis formula》

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a BC=acute toxicity assay of blank control group，‘a’=‘acute’.Same as below.

The animals were divided into 21 groups of ten animals each（five males and five females）.The scheme used for grouping was shown in Table 1.The doses of Realgar used in each group were designed according to the results of a pilot study.All treatments were administered once by oral gavage.The animals were closely observed for 4 h following administration and then once daily for14 d to evaluate general behavior，clinical signs of toxicity and mortality.Body weights were measured before and after administration and on days 7 and 14.At the end of the experiment，the animals were anesthetized using pentobarbital sodium（45 mg/kg i.p.）.After the animal was deeply anesthetized，it was euthanized via cervical dislocation，and the following organs were removed for histopathological analysis:the brain，heart，lungs，liver，stomach，small intestine（section），testicle（ovarian），and kidneys.