《Table 1 Clinical characteristics of the study subjects》

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《Measurement of prostaglandin metabolites is useful in diagnosis of small bowel ulcerations》

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1Mann-Whitney U-test or Fisher’s exact test.Data are the number（%）or median（interquartile range）.Significant P values are indicated in bold.CEAS:Chronic enteropathy associated with SLCO2A1 gene；CD:Crohn disease；CRP:C reactive protein.

Among the participants of our previous studies[10，16，17]and the patients diagnosed as CEAS or CD at Kyushu University hospital，we enrolled 20 Japanese patients with CEAS and 98 patients with CD for the present investigation.A diagnosis of CEAS was confirmed based on published clinical criteria[18，19]with genetic analysis（Supplementary Table 1）.The diagnosis of CD was based on the Japanese diagnostic criteria for CD[20].No patients were administrated prostaglandin analogues or NSAIDs at the time of urine sample collection.All urine and blood samples were collected after obtaining written informed consent.This study was approved by the institutional review board at each collecting site in accordance with the Declaration of Helsinki Principles.