《Table 1 Demographic and clinical characteristics of the study groups based on the diagnosis in 168

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《Bruch's membrane opening-minimum rim width and visual field loss in glaucoma:a broken stick analysis》

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aMann-Whitney U test；bχ2 test；cStudent’s t-test.VF:Visual field；VFI:Visual field index.

One hundred sixty-eight participants（85 normal and 83 glaucoma subjects）were enrolled in the study.The demographic，clinical，and ocular characteristics of the participants are summarized in Table 1.The global BMO-MRW of the glaucoma patients was significantly thinner than that of the normal subjects，256.3±48.9μm for the normal subjects and 163.8±37.9μm for the glaucoma patients（P<0.001）.The number of glaucoma patients whose sectoral BMO-MRW values followed the ISNT rule was significantly lower than the normal subjects，with 31（36.5%）for the normal subjects and 3（3.6%）for the glaucoma patients（P<0.001；Table 2）.The global indices of the VF for glaucoma patients were significantly worse than the normal subjects.The VF MD was-1.22±1.91 d B for the normal subjects and-7.06±5.38 d B for glaucoma patients（P<0.001）.Scatterplots of the global，sectoral BMO-MRWs and corresponding VF TD values are shown in Figures 2 and 3.A range of BMO-MRW values was unrelated to the VF TD values，followed by a range of BMO-MRW values which was strongly related to the VF TD values（Figure 2A）.Statistically optimal locations of the tipping points between these two ranges in the global and sectoral BMO-MRW values are summarized in Table 3.The locations of the tippingpoints were statistically significant for all of the locations（all P≤0.006；Davies’test）.The percentages of BMO-MRW loss for the tipping points were calculated for the global and sectoral BMO-MRW values using the mean BMO-MRW values for the normal subjects.The tipping point for the global BMO-MRW measurement occurred after a 25.9%loss from the mean normal BMO-MRW value.Using sectoral analyses，the percentage of BMO-MRW loss was highest for the superonasal sector（34.9%）and was lowest loss for the temporal sector（6.6%），with a range of 8.9%-34.4%for all of the other sectors（Table 3）.