《Table 2 Stratified analysis of overall survival in GSE14520 and The Cancer Genome Atlas cohorts》

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《Seven-senescence-associated gene signature predicts overall survival for Asian patients with hepatocellular carcinoma》

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a Statistically significant.HR:Hazard ratio；CI:Confidence interval；AFP:Alpha-fetoprotein.

To confirm the potentiality of the seven-SAG prognostic model，Kaplan-Meier curve was carried out to evaluate the association between the overall survival（OS）and our gene signature in discovery（GSE14520）and validation（TCGA-LIHC）cohorts.The whole group was divided into the high-and low-risk subgroups according to the median of all patients’risk scores.In the discovery cohort，with the increase in the risk score，the expression of all the seven genes was increasing，and the death events accumulated（Figure 4A）.The patients in the high-risk subgroup had a 1.92-fold higher death risk than the low subgroup[hazard ratio（HR），95%confidence interval（CI）=1.92，1.16-3.19；log-rank P value=0.011]（Figure 4B）.We then tempted to test these findings in the validation cohort（TCGA-LIHC）（Figure 4C） .Similar to the findings obtained from the discovery cohort，patients in the high-risk group[median survival time（MST）=46.6 m]had significantly shorter OS time than patients with a low-risk score（MST=70.5 m）[HR（95%CI）=1.80（1.27-2.54），log-rank P value=0.001]（Figure 4D）.Interestingly，when we analyzed the data in the Asian population，we observed a highly significant association between the seven-SAG signature and OS.The majority of death events occurred in the high-risk group（Figure 4E）.Asian HCC patients with a high-risk score were shown to have a>5-fold increased death risk than low-risk patients[HR（95%CI）=5.81（3.20-10.54），log-rank P value<0.0001].The MST of the high-risk subgroup was only 60%of that of the low-risk group（MST=21.6 m vs 91.7 m）（Figure 4F） .In order to investigate the prognostic value of the risk score system in different patient groups with different characteristics，we performed univariate/multivariate Cox regression analysis of clinicopathologic factors associated with OS in the discovery and validation cohorts.From the Cox regression results，both the seven-SAG signature and serum AFP level were confirmed to be independent risk factors of OS in the two cohorts（Table 1）.