《Table 2 Univariate and multivariate analyses of factors in relation to overall survival》

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《Albumin-to-alkaline phosphatase ratio: A novel prognostic index of overall survival in cholangiocarcinoma patients after surgery》

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HR:Hazard ratio；AAPR:Albumin-to-alkaline phosphatase ratio；HBV:Hepatitis B virus；HCV:Hepatitis C virus；CCA:Cholangiocarcinoma；ALP:Alkaline phosphatase.

The baseline clinical characteristics are presented in Table 1.In total，303 CCA cases were enrolled in this study.The median age was 59（range 29–83）years old.Overall，168 subjects were males and 135 were females，with a male-to-female ratio of 1.2:1.Of the 303 CCA patients，10.23%（31 subjects）and 1.65%（five subjects）were positive for HBV and HCV infection，respectively.The median follow-up duration was 21.0 mo.In total，177 patients passed away during the study，with an estimated median OS of 16.8mo（range:1.0-75.0 mo）.The 1-year，3-year and 5-year survival rates were 75.6%，48.7%and 26.8%，respectively.