《Table 2 Univariate and multivariate analyses of variables influencing survival of 52 patients with

  提示：宽带有限、当前游客访问压缩模式

本系列图表出处文件名：随高清版一同展现

《Functional role of long non-coding RNA CASC19/miR-140-5p/CEMIP axis in colorectal cancer progression in vitro》

1. 获取 高清版本忘记账户？点击这里登录

1. 下载图表忘记账户？点击这里登录

a P<0.05.b P<0.01.CASC19:Cancer susceptibility 19；CRC:Colorectal cancer；Exp（B）:The exponent of B；CI:Confidence interval.

We also focused on determining the association between expression of CASC19 and clinical phenotypes of patients with CRC.Participants were stratified into an aggressive tumor group（n=25）and a non-aggressive tumor group（n=27）based on whether the patient had or not lymph node or liver metastasis.Results showed that aggressive CRC tumors had higher CASC19 expression（P<0.05）（Figure 1C） .Next，we calculated the average of relative CASC19 expression levels in tumor tissues，and the average value（2.9310）was determined to be the cutoff point between“High CASC19”and“Low CASC19”.Results showed that 22 samples were included in the high CASC19 group while another 30 were included in the low CASC19 group.Subsequent correlation analysis revealed that CASC19 expression was associated with liver metastasis（P<0.01），lymphatic metastasis（P<0.01），and TNM stage（P<0.05）（Table 1）（Supplementary Figure 1）.Significant associations were not present between CASC19 expression and other clinical parameters such as tumor size，local invasion，age，and gender（P>0.05）（Table 1） .Kaplan-Meier survival curves demonstrated that patients who possessed raised expression of CASC19 experienced shorter survival durations in contrast to those who had lower CASC19 expression（log-rank P<0.001）（Figure 1D） .We then carried out multivariable Cox regression analysis to further determine the impact of clinicopathological features and expression of CASC19 on the overall survival times of patients with CRC.The findings indicated that CASC19expression[the exponent of B（Exp (B）=8.893，95%confidence interval（CI）:2.596-30.464，P=0.001]was an independent prognostic factor for CRC（Table 2）.