《Table 2–The physical appearance, particle size, size distribution, zeta potential and entrapment ef

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《"Vesicular carriers containing phenylethyl resorcinol for topical delivery system; liposomes, transfersomes and invasomes"》

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The size decreased together with the formulation containing surfactants with high HLB value.In this study it was found that the surfactant with high HLB（Tween 80，HLB=15；SDC，HLB=16；Tween 20，HLB=16.7）gave smaller size than the surfactant with low HLB（Span 20，HLB=8.6）as shown in Table 2.Transfersomes containing Tween 80，SDC and Tween20 gave a mean vesicles size of 350.40±4.60，353.70±10.90and 387.50±4.80 nm，respectively，while the vesicle size of991.30±330.60 nm was obtained from the formulation containing Span 20 when prepared by the same concentration.The surfactant with low HLB might be attributed to enhance surface free energy through increasing hydrophobicity，by interacting with lipid head groups of the membrane，which increase packing density of phospholipid layer leading to increase surface free energy that causes fusion between lipid bilayers to form a large vesicle[23].However，Span 80 has low HLB with strongest hydrophobicity.That may cause the aggregation between vesicles，to form larger vesicle and tend to precipitate.In this study，the formulation containing Span 80as edge activator becomes precipitated after preparation.The pdI，zeta potential and%EE of all transfersomes are as demonstrated in Table 2.The PDI of all formulations were in the range of 0.093±0.046 to 0.285±0.020 which were within 0.3 indi-cating that the population of the vesicles was homogeneous.The zeta potential of all transfersome formulations were high negative charge（-41.86±0.73 to-68.55±2.56）.High negative zeta potential represents a good stability of the formulations.