《Table 2.Blood glucose in Zucker diabetes fatty rats receiving Glucophagevs.Meidikang.》

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《二甲双胍原研制剂格华止~与一种仿制制剂在大鼠模型中药代动力学和药效学比较（英文）》

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Data are shown as mean±SD（n=6）.Results were analyzed using independent sample t-test.*P<0.05.

In rats treated with high-dose Glucophage?，fasting plasma glucose was significantly lower at the 6th week compared with the baseline（P=0.01）.In rats treated with Meidikang?，there was a trend（not statistically significant）for lower fasting plasma glucose at the 6th week compared with the baseline（P=0.77）.However，in the low-dose groups，the changes in fasting blood glucose were not statistically significant（P>0.05；Table 3）.ANOVA analysis showed that fasting plasma glucose at the 6th week in both the Glucophage?groups and the high-dose Meidikang?group were lower than that in rats receiving distilled water（P<0.001，P=0.02for 300 mg·kg–1·d–1 of Glucophage?and the generic drug，respectively；P=0.01 for 180 mg·kg–1·d–1of Glucophage?）.Moreover，there were significant differences between the rats receiving Glucophage?and generic metformin（11.6±1.3 mmol/L vs.15.3±2.0 mmol/L for the high-dose groups，P=0.002；14.9±1.7 mmol/L vs.16.9±1.2 mmol/L for the low-dose groups，P=0.03）.Data were shown in Table 3.