《Table 1 mACE2-rAAV2/8 therapy increased hepatic ACE2 expression, resulting in a marked reduction in

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《Current therapies and novel approaches for biliary diseases》

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We have now confirmed the effectiveness of this treatment strategy in Mdr2-KO mice，a long-term animal model with progressive hepato-biliary fibrosis.This model，which has been widely used for studies that investigated pathophysiology of biliary fibrosis，produces lesions that resemble those of human PSC[63-65].Gene therapy using the AAV2/8-mACE2 vector was very effective in Mdr2-KO mice，showing 50%and80%reduction in liver fibrosis in both established and advanced liver disease，respectively（Table 1）.