《Table 1 Studies of pharmacological therapies with immunomodulatory properties in animal models of A
本系列图表出处文件名:随高清版一同展现
《Amelioration of Alzheimer's disease pathology and cognitive deficits by immunomodulatory agents in animal models of Alzheimer's disease》
The pharmaceutical therapies were with fasudil,LW-AFC,curcumin,TNF inhibitor XPro1595,IL-1 receptor antagonist(IL-1RA),pioglitazone,rosiglitazone,quercetin,IL-1β,cannabidiol,multi-targeted diet(zinc,melatonin,curcumin,piperine,eicosapentaenoic acid,docosahexaenoic acid,uridine,choline),and clioquinol.These have all been shown to have immunomodulatory properties(fasudil:Thorlacius et al.,2006;Song et al.,2013;Liu et al.,2015;LW-AFC:Wang et al.,2016;curcumin:Gaulam et al.,2007;TNF inhibitor XPro1595:Fischer et al.,2015;IL-1RA:Granowitz et al.,1992;Nedumpun et al.,2017;pioglitazone:Singh et al.,2011;El-Sisi et al.,2015;rosiglitazone:Liu et al.,2009;Serghides et al.,2009;quercetin:Li et al.,2016;Casas-Grajales et al.,2017;IL-1β:Chen et al.,2010;cannabidiol:Mecha et al.,2013;Zgair et al.,2017;memantine:Lowinus et al.,2016;Lee et al.,2015;melatonin:Giannoulia-Karantana et al.,2006;Medrano-Campillo et al.,2015;piperine:Sunila and Kuttan,2004;Rodgers et al.,2009;eicosapentaenoic acid:Iwami et al.,2011;Hirahashi et al.,2014;decosahexaenoic acid:Koch et al.,2006;Hjorth and Freund-Levi,2012;uridine:Abood et al.,2014;choline:Pavlov et al.,2003;Parrish et al.,2006;Parrish et al.,2008;Rowley et al.,2010;clioquinol:Kidd et al.,2016).The thirteen animal studies utilizing these pharmaceutical agents are summarized in Table 1.Eleven of these studies had used mouse models,and two a rat model.In the mouse studies,the ages of the animals at which treatment was started ranged from 6 weeks to 21 months and where gender was specified 4 had used males,3 females,and 2 both males and females.The rat studies had used males,with ages ranging from 8 weeks to 4 months.The treatment period with the pharmacological agent ranged from 30 days to 5 months.
图表编号 | XD0040618400 严禁用于非法目的 |
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绘制时间 | 2019.07.01 |
作者 | Bridget Martinez、Philip V.Peplow |
绘制单位 | Department of Molecular & Cellular Biology,University of California、Department of Medicine,St.Georges University School of Medicine、Department of Physics and Engineering,Los Alamos National Laboratory、Department of Anatomy,University of Otago |
更多格式 | 高清、无水印(增值服务) |
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