《Table 1 IRs (%, means±S.D.) of the crude extracts at concentrations of 2.5, 400, 50, and 200μg/mL,

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《Algicidal activities of secondary metabolites of marine macroalgal-derived endophytic fungi》

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“-”means no further experiments were conducted because of the weak algicidal activities in preliminary tests.

Among them，11 compounds were considered to have strong algicidal activities（Tables 2 and 3）.None of the C.marina cells could survive treatment with compounds 1，2，4，5，6，1 7，2 1，2 4，2 6，and 3 0 at a fi nal concentration of 5μg/mL（Table 2），and their24 h EC 50 values ranged from 0.01 to 1.50μg/mL（Table 3）.Compounds 2，4，and 5，at a fi nal concentration of 40μg/mL，showed strong algicidal activities against A.tamarense with IR values higher than 95%（Table 2），and their 24 h EC 50 values were in the range of 2.37–5.24μg/mL（Table 3）.Similarly，at a fi nal concentrations of 2.5μg/mL，compounds 1，2，4，1 7，2 4，and 2 6 showed intense algicidal activities against H.akashiwo with IR values higher than 95%（Table 2），and their 24 h EC 50 values ranged from 0.63to 1.80μg/mL（Table 3）.The IRs of compounds 1 and2 7 against P.donghaiense were both higher than 90%at a concentration of 20μg/mL（Table 2），and their24 h EC 50 values were 4.24 and 14.29μg/mL，respectively（Table 3）.