《Table 1 AJCC pathological classification (pTNM)》

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《Update on pathology of retinoblastoma》

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Pathological Tumor，Node，Metastasis Classification Tumor，node，metastasis（TNM）classification is developed by the American Joint Commission on Cancer（AJCC）and the Union International Control Cancer（Table 1）[25].Retinoblastoma is the first cancer in which role of germline predisposition is recognised by incorporating stage category“H”into the AJCC classication[26].Table 2 describes the AJCC 2017 8th edition tumor，node，metastasis，heritable trait（TNMH）clinical（c）and pathological（p）staging system which is known to be the first evidence-based system for predicting overall prognosis of both eye（s）and patients[27-28].