《Table 2Patient characteristics according to post-operative ALBI grade.》

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《Post-operative albumin-bilirubin grade predicts long-term outcomes among Child–Pugh grade A patients with hepatocellular carcinoma after curative resection》

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:Values shown as median[interquartile range（IQR）]；:Postoperative complication was defined as≥grade III according to Clavien–Dindo classification.NA:not available.

Spearman’s rank correlation test showed that there was no significant correlation between the amount of administered albumin during operation and pre-/postoperative serum albumin values（rho=-0.13 and-0.15，respectively；P>0.05；Fig.3）.The number of patients with post-operative ALBI grade I（post-op grade I），II（post-op grade II）and III（post-op grade III）were 1（1.3%），59（73.8%），and 20（25.0%），respectively（Table 2）.Within these groups，repeated hepatic resection（P=0.012），bleeding during surgery（P=0.006）and surgery duration（P=0.033）were confounding to post-operative ALBI grade.Both overall survival and recurrencefree survival were worse in the post-op grade III group than those of the post-op grade II group（Fig.4）；the 1-，3-，and 5-year overall survival rates were 93.1%，93.1%，and 81.1%，respectively，in the post-op grade II group，and 80.0%，68.9%，and 55.1%，respectively，in the post-op grade III group（P<0.001）.The 1-，3-，and 5-year recurrence-free survival rates were 86.0%，54.3%，and 47.2%，respectively，in the post-op grade II group，and 52.8%，29.3%，and 19.5%，respectively，in the post-op ALBI grade III group（P=0.015）.Multivariate analysis of survival revealed that post-operative grade was an independent risk factor of death and recurrence[post-op grade III vs.post-op grade II:for overall survival，P=0.035（Table 3）；and for recurrence-free survival，P=0.024（Table 4）].