《Table 2 Advantages and disadvantages of animal models for filovirus infections》

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《Animal models for filovirus infections》

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NHPs:Non-human primates.

Animal models against filoviruses have been developed in mice，guinea pigs，hamsters，ferrets and NHPs（Bente et al.，2009；Bradfute et al.，2012；Connolly et al.，1999；Marzi et al.，2016；Kozak et al.，2016；Kroeker et al.，2017b；Yamaoka et al.，2017）.The development of animal models that recapitulates hallmarks of human filoviral disease is crucial in understanding the pathogenesis of these viruses.In this review，we summarize the animal models that have been developed for filoviruses（Table 1），and discuss the advantages and disadvantages of each animal model（Table 2）.