《Table 1 Summary of experimental parameters and results of Ifnar–/–mice challenged with various outb

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《Type Ⅰ interferon receptor knockout mice as models for infection of highly pathogenic viruses with outbreak potential》

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IM:Intramuscular；IN:Intranasal；SC:Subcutaneous；IP:Intraperitoneal；ID:Intradermal；IV:Intravenous.

Immunocompromised Ifnar–/–mice have been shown to be a very good alternative small animal model for highly virulent pathogens that do not cause disease in immunocompetent mice.In this review，we described the different parameters and results from experimental infection of Ifnar–/–mice with various pathogens（Table 1）.It is obvious that the advent of Ifnar1–/–mice undoubtedly constituted a major step forwards in allowing researchers to easily and rapidly study the pathogenesis of clinical isolates during a potential outbreak situation，as these animals are more susceptible to viral infections（Table 2）.