《Table 1–Results of irinotecan hydrochloride (nano) micelle interference test.》

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《LAL test and RPT for endotoxin detection of CPT-11/DSPE-mPEG_(2000) nanoformulation: What if traditional methods are not applicable》

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The results are listed in Table 1.For both LAL reagents（manufactured by Zhanjiang A&C and Xiamen Limulus Reagent Company），the endotoxin free water showed negative results and the endotoxin positive controls（Group 1）showed the sensitivity of detection ES=λ，indicating that LAL results are valid.However，for samples 20150325DM and 20150427DM，the two kinds of LAL reagents behaved significantly differently.The results from LAL reagent manufactured by Zhanjiang A&C Biological Co.，Ltd.showed that with 20150427DM，the sensitivity of detection Etis not between 0.25λ-2λ，which indicated that0.125 mg/ml sample concentration causes interference for the reaction between LAL reagents and endotoxin.On the other hand，the LAL reagent manufactured by Xiamen Limulus Reagent Experimental Factory Co.，Ltd.generated all positive results，including negative controls of samples 20150325DM and20150427DM.These results demonstrated that at a drug concentration of 0.125 mg/ml，the irinotecan hydrochloride（nano）micelle interferes with the LAL test.