《Table 2 Correlations between brain-derived neurotrophic factor levels and clinical and experimental

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《Increased expression of brain-derived neurotrophic factor is correlated with visceral hypersensitivity in patients with diarrheapredominant irritable bowel syndrome》

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Spearman’s correlation coefficients are presented with P-values in parentheses.a P with significance after Bonferroni correction（adjusted P<0.0071）.b P without significance after Bonferroni correction（adjusted P<0.0071）.BDNF:Brain-derived neurotrophic

The demographics，clinical characteristics and psychological assessments of IBS-D patients and controls are presented in Table 1.There were 31 IBS-D patients（22 males and 9 females；median age 33.0 years，IQR:29.0-42.0）and 20 healthy controls（13males and 7 females；media age 28.0 years，IQR:26.0-36.0）participating in this study.There were no statistically significant differences in terms of age，gender，or body mass index between the groups.The average IBS-SSS score was 274.0（SD=29.8）and the median duration of disease was 5.0 years（IQR:2.0-10.0）in the IBS-D group.The median pain intensity for IBS-D patients was mild.Scores of VSI（IBS-D:median 54.0，IQR:44.0-61.0；control:21.0，17.3-30.0，P<0.01）and anxiety（IBS-D:median 6.0，IQR:2.0-10.0；control:3.0，1.0-4.0，P=0.003）were significantly elevated in IBS-D patients.The depression score tended to increase in the IBS-D group but the difference failed to reach the significant level（P=0.055）.