《Table 1 Demorgraphics, clinical characteristics and psychological states of patients with diarrhea-

《Table 1 Demorgraphics, clinical characteristics and psychological states of patients with diarrhea-   提示:宽带有限、当前游客访问压缩模式
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《Increased expression of brain-derived neurotrophic factor is correlated with visceral hypersensitivity in patients with diarrheapredominant irritable bowel syndrome》


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a P<0.01 vs controls.The data are presented as the mean±standard deviation or median(interquartile range).IBS-D:Diarrhea-predominant irritable bowel syndrome;IBS-SSS:IBS Symptom Severity Scale;VSI:Visceral sensitivity index;HADS:Hospital Anxiety and Dep

In IBS-D patients,BDNF protein expression was positively correlated with severity of abdominal pain and IBS-SSS score,and negatively correlated with the first sensation threshold and RAIR threshold(adjusted P<0.0071).However,the association between BDNF protein expression and IBS-SSS score lost significance after Bonferroni correction(Table 2).In all subjects,a significantly negative correlation was found between mucosal BDNF levels and the first sensation threshold,maximum tolerable threshold and RAIR threshold(adjusted P<0.01)(Table 3) .We found no correlations between BDNF levels and other characteristics(P>0.05).