《Table 4Body mass gain in mice after 30 days of feeding》

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《传统发酵食品臭鳜鱼中分离的苏云金芽孢杆菌(Bacillus thuringiensis 29.118)的毒理学评价（英文）》

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Note:For both the male and female mice，the body weights from different treatments of dose（500，1 000，2 000 mg/kg mb）did not represent significant differences compared to the normal saline among four different periods (initial weight，week 1，week 2，we

All the mice survived the 30-day feed test，and no distinct clinical signs of toxicity were found.Initial weights of both male mice and female mice were about 22 g.The final weights of the control and three treatment groups reached38 g after a 4-week feed.The body weight of the treatment mice did not show significant differences compared to the control.The growth and development of mice for all the given doses showed well（Table 4）（P>0.05） .Seven items of serum（AST，ALT，GLU，TG，T-SOD，GSH-Px and BUN）and three liver homogenate items（GSH-Px，T-SOD and MDA）were measured to analyze the biochemical indexes.There were no significant differences between the treatment and the control for the tested parameters（P>0.05）.The cell injury of the liver was observed by H&E staining.The homogenate MDA of liver from the high-dose group was significantly different compared to the control（P<0.05）.The sections of the liver from the control indicated that the healthy liver cell had the basic features of intact organization structure，clear cell boundary and the bright dyeing.No distinct clinical symptoms of toxicity were found after 30days feed，and no pathological symptoms were also found in the autopsy.The cells of degeneration and necrotic inflammation were not observed（Fig.3A）.The dose resulted in the formation of hemocyte cell on the wall of hepatic sinusoid.Distinct space was found among the cells from high-dose groups（Fig.3B）.Therefore，the cell walls of all three treatment groups still kept intact，and the significant pathological symptoms are not found.