《Table 1 The association between LINE-1 methylation level and high myopia》

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《Genome-wide DNA hypermethylation and homocysteine increase a risk for myopia》

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Refraction:Diopter of the worse eye.High myopia:Subjects with refraction error≤-6 D；Control:Refraction error between 0.75 D and-1.5 D；High Edu:College or higher education level；The range of LINE-1 methylation level（presented as%）for upper title (82.23%-

DNA Methylation in Human Subjects Based on the DNA availability and quality，220 highly myopic cases and 220sex-and age-matched controls were used for this study.The demographic data and LINE-1 methylation levels of study subjects are shown in Table 1.The mean refraction error and standard error of mean（SEM）were-8.81±0.14 D for myopic subjects and-0.53±0.04 D for control subjects.The myopic subjects had a higher percentage for a college or higher education level than controls，while sex and age had no significant difference between the cases and controls（Table 1）.The LINE-1 methylation level was significantly higher in the myopic subjects than controls（P=0.003，Table 1）.We further divided the total population into tertiles.Accordingly，there were 87 cases and 60 controls in the upper tertile，73 cases and74 controls in the middle tertile and 60 cases and 86 controls in the lower tertile（Table 1）.Most myopic subjects were in the upper（methylation level:82.23%-91.50%）or middle tertile（methylation level:79.53%-82.23%），while most control subjects were in the low tertile（methylation level:70.80%-79.53%）.In the multivariate analysis，the OR of high myopia was 2.19（P=0.001）for the upper tertile and 1.76（P=0.021）for the middle tertile compared with the lower tertile（Table 1）.