《Table 7Associations between phenotypes and genotypes of AMR in H.parasuis strains.》

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《越南广平和顺化两省猪场分离副猪嗜血杆菌的抗生素耐药表型和耐药基因之间的相关性研究》

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This study is the first investigation on the prevalence of AMR and ARGs of H.parasuis isolates from swine in Central Vietnam.The strains tested were resistant to a broad range of antimicrobial agents with high MIC values，and high rates of multi-resistance were observed.The distribution of the most common resistance genes in the H.parasuis isolates included blaTEM-1，int，gyrA，and rmtD.This study also identified a number of ARGs that are clearly correlated with most of the AMR phenotypes observed in the H.parasuis strains.The results suggest that the use of some of the antimicrobials that show a high resistance frequency should be limited，while fluoroquinolones，TIA，FFC，and DOX can still be used in clinics in Vietnam to control Gl?sser’s disease.Moreover，the network of associations identified in this study will be useful for the development of policy and clinical practice guidelines to minimize AMR in Vietnam.It has been suggested that current attempts to limit the spread of AMR based on the prudent use of antimicrobials may prevent the selection of genes conferring resistance.Hence，assessment of AMR at the genetic level and the identification of associations between the phenotype and genotype resistance are critical tools in devising guidelines for the control of AMR.