《Table 1.Summary of different types of bioactive signals and delivery strategies in bone tissue engi

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《Biomimetic delivery of signals for bone tissue engineering》

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The importance and complexities of bioactive signal molecules in regulating cellular activities and bone healing suggests that DDSs mimicking the natural healing process are more likely to achieveadvantageous therapeutic effects and thereby the desired bone regeneration outcome.Various methods and strategies have been exploited to enable spatiotemporal control over the drug release kinetics（Fig.1 and Table 1）.