《Table 2Univariate analyses of immediate postoperative predictive risk factors for postoperative ER
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《Preoperative risk factors for early recurrence in patients with resectable pancreatic ductal adenocarcinoma after curative intent surgical resection》
*Postoperative complications were classified according to the Clavien–Dindo’s classification.ER:early recurrence;PDAC:pancreatic ductal adenocarcinoma;UICC:International Union Against Cancer.
ER occurred in 26 patients(32.1%).Among non-ER patients,49(60.5%)had late recurrence,6(7.4%)had no recurrence.The incidence of liver metastasis was significantly higher in the ER group than in the non-ER group(53.8%versus 10.4%,P<0.01).The incidence of local recurrence(23.1%versus 39.6%)and distant metastasis(23.0%versus 50.0%)were lower in the ER group compared to that in the non-ER group.Univariate analysis using only preoperative variables was done to predict ER in patients with R-PDAC.Results showed that operative time≥500 min,CRP>3.0 mg/dL,m GPS score=2,decrease of total lymphocyte count>50%of baseline value,PNI<45,neutrophil-to-lymphocyte ratio(NLR)≥3,and preoperative SUVmax were significantly associated with the occurrence of ER in patients with R-PDAC(Table 1).Univariate analysis using immediate postoperative variables showed UICC stage,pT stage and pathological grade were significantly associated with the occurrence of ER in patients with R-PDAC(Table 2).Distribution of patients receiving adjuvant chemotherapy was not significantly different between ER group and non-ER group(84.6%versus 74.5%,P=0.397,Table 2).Among the preoperative factors,a multivariate logistic regression analysis with forward stepwise conditional method revealed that CRP>3.0 mg/dL,decrease of total lymphocyte count>50%of baseline,and preoperative SUVmax were significant and independent contributors to the occurrence of ER in patients with R-PDAC(Table 3).Overall,the 1-,2-,3-,and 5-year survival rates in the non-ER group and ER group were 90.2%,67.7%,49.9%,and 13.2%,versus 37.9%,0%,0%,and 0%,respectively(P<0.01,Fig.1).And non-ER group had longer median survival time than ER group(23 months versus 10 months,Fig.1).
图表编号 | XD0020454900 严禁用于非法目的 |
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绘制时间 | 2018.10.15 |
作者 | Nam Hee Kim、Hong Joo Kim |
绘制单位 | Division of Gastroenterology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine、Division of Gastroenterology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of |
更多格式 | 高清、无水印(增值服务) |
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