《Table 5 Chemokine GPCRs in inflammation and immunity》

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《Chemokines in homeostasis and diseases》

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Abbreviations:CCR，C-C cchemokine motif receptor；COPD，chronic obstructive pulmonary disease；CXCL，C-X-C cchemokine motif ligand；CXCR，C-X-Ccchemokine motif receptor；IBD，inflammatory bowel disease；GPCR，G-protein coupled receptor；HIV，human immunodeficien

Chemokines and their GPCRs are associated with an extraordinary array of pathological conditions52–55（Table 5），including autoimmune disorders8，56–61（for example，psoriasis，rheumatoid arthritis and multiple sclerosis）；pulmonary diseases62–65（for example，asthma and chronic obstructive pulmonary disease）；transplant rejection70，71；metabolic and vascular diseases66–69，78（for example，obesity，diabetes and atherosclerosis；as well as infectious diseases72–77 (for example，HIV，sepsis and inflammatory bowel disease）.The active participation of chemokines and GPCRs in disease progression makes these molecules the most prominent targets for drug development.