《Table 2 Toxicity results》

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《Stereotactic body radiation therapy for non-small cell lung cancer:A review》

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RTOG:Radiation therapy oncology group；JCOG:Japan clinical oncology group；Inop:Medically inoperable；Op:Medically operable；DLCO:Diffusing capacity of the lungs for carbon monoxide；PFT:Pulmonary function test.

Nineteen studies meeting our criteria were selected for inclusion in this review（Table 1）.Publication years ranged from 2005 to 2017.The mean number of patients included in the trials was 75（range 31 to 180），with a median follow-up between 16 to86 mo.Dose fractionation schedules varied widely.Using aα/βratio of 10，the total biologically effective doses（BED）included were>100 Gy10 in almost all studies，except for two.Shibamoto et al[6]treated four patients，whose tumors were less than1.5 cm in diameter，with 44 Gy in 4 fractions.Similarly，a small number of patients were treated with BED<100 Gy in the dose escalation study authored by McGarry et al[7].