《Table 2 General clinical data of patients》

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《Expression and predictive value of miR-489 and miR-21 in melanoma metastasis》

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The expression levels of miR-489 in serum of patients with TNM stages I-IV melanoma were 0.62±0.29，0.48±0.24，0.47±0.22，and 0.31±0.17，respectively；the corresponding values for miR-21 were 3.60±1.79，5.28±2.13，5.23±2.01，and 7.01±2.47).Compared with patients with Hoehn-Yahr grade I，the relative expression of miR-489 and miR-21 in serum of patients with grades II and III decreased significantly（P<0.05）.With the increase of TNM stage，the relative expression of miR-489 in serum decreased，while the relative expression of miR-21 in serum increased continuously.Spearman correlation analysis of the relative expression of serum miR-489 and miR-21 in melanoma of different TNM stages showed that the relative expression of serum miR-489 was negatively correlated with melanoma TNM stage（r=-0.612，P<0.001），while the relative expression of serum miR-21 was positively correlated with TNM stage of melanoma（r=0.609，P<0.001）.More details are shown in Figure 3A-D.