《Table 2 The precision, repeatability, stability and recovery of established AA analysis methods》
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《Metabolic profile analysis of free amino acids in experimental autoimmune uveoretinitis rat plasma》
AA:Amino acid;RT:Retention time;PA:Peak areas;AR:Average recoveries.
In this study,we found that plasma AAs was significant difference between EAU and control group.There were 9 kinds of AAs in EAU rats whose concentrations were lower than in control group,5 kinds of AAs were higher in EAU(Figure 3,Table 3).Notably among these AAs,Tyr,Gly,Met,His,Ala,Glu,Try,Pro and Asp were decereased,while the levels of Leu,Thr,Val,Iso and Cys were increased.The most decreased AA was Tyr,which is the essential AA,and related to Tyr with dopa,dopamine,norepinephrine and epinephrine,and also the product of metabolism of phenylalanine.In this study,the content of Phe was hardly changed.In contrast,the most increased AA was Leu,demonstrating that signal transduction pathways related to Leu may contribute to interpretation of cellular signals[34].Moreover,AAs can also influence protein by regulating protein synthesis and degradation.Because of Tyr,Leu,Gly and Met represent a biologic molecules exerting dynamic,highly disparate physiologic processes in EAU.Thus,we have applied an analytical tools to understand of AA in EAU.
图表编号 | XD0032747200 严禁用于非法目的 |
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绘制时间 | 2019.01.18 |
作者 | Jun-Guo Guo、Xin-Miao Guo、Xing-Rong Wang、Jing-Zhen Tian、Hong-Sheng Bi |
绘制单位 | College of Pharmacy,Shandong University of Traditional Chinese Medicine、Shandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases、Eye Institute Shandong University of Traditiona |
更多格式 | 高清、无水印(增值服务) |
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